=== Failed - File system specific implementation of LookupAndOpen[file] failed === 1. Enable SSH access to your ESXi host and login 2. Check the main .vmdk file if it corrupted or not vmkfstools -x check /path/to/your/machine.vmdk 3. To repair the file type: vmkfstools -x repair /path/to/your/machine.vmdk 4. Start you VM!